Activities per year
The development of liposome-nanoparticle colloid systems offers a versatile approach towards the manufactureof multifunctional therapeutic platforms. A strategy to encapsulate small metallic nanoparticles (< 4 nm) withinmultilamellar vesicles, effected by exploiting electrostatic interactions was investigated. Two liposome-goldnanoparticle (lipo-GNP) systems were prepared by the reverse-phase evaporation method employing cationic oranionic surface functionalised particles in combination with oppositely charged lipid compositions withsubsequent post-formulation PEGylation. Structural characterisation using electron microscopy and elementalanalysis revealed a regular distribution of GNPs between adjacent lipid bilayers of intact liposomes. Nanoparticleencapsulation efficacy of the two lipo-GNP systems was revealed to be significantly different (p=0.03),evaluated by comparing the ratio of measured lipid to gold concentration (loading content) determined by acolorimetric assay and atomic emission spectroscopy, respectively. It was concluded that the developed syntheticstrategy is an effective approach for the preparation of liposome-nanoparticle colloids with potential to controlthe relative concentration of encapsulated particles to lipids by providing favourable electrostatic interactions.
|Number of pages||9|
|Journal||European Journal of Pharmaceutical Sciences|
|Publication status||Published - 3 May 2017|
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- School of Applied Sciences - Principal Lecturer
- Chemistry Research and Enterprise Group
- Environment and Public Health Research and Enterprise Group
- Biomaterials and Drug Delivery Research and Enterprise Group
- Centre for Aquatic Environments
- Centre for Stress and Age-Related Disease
- Advanced Engineering Centre
- Centre for Regenerative Medicine and Devices
Masters Degree by Research (France) - Mr Victor Jasny (University of Tours at Blois)
Dipak Sarker (Supervisor)1 Mar 2020 → 1 Aug 2020
Activity: External examination and supervision › Research degree
Nanosystems for in-vivo self-assembling medical devices.
Dipak Sarker (Presenter)14 Nov 2014 → 15 Nov 2014
Activity: External talk or presentation › Invited talk