Peroxisome proliferator activated receptors (PPARs) are ligand-activated transcription factors andmembers of the nuclear hormone receptor superfamily. PPARβ/δ is ubiquitously expressed andhas a central role in homeostasis, and has been suggested as a therapeutic target for a number ofmetabolic and cardiovascular disorders. This important nuclear receptor controls transcriptionunder different modes of molecular activity which directly control the cellular function and fate oftissues. This complex activity of induction and transrepression of gene expression (with and withoutexogenous ligands) is poorly understood and yet understanding this molecular control throughnovel drug development would led to control over a key molecular switch in all cells. This reviewoutlines the main molecular mechanisms of PPARβ/δ, and links the modes of activity to thesignalling pathways in inflammation, proliferation and senescence, with the goal to understand howthis will translate into novel drug design to control the PPARβ/δ molecular switch.
|Number of pages||11|
|Journal||Annual Research and Review in Biology|
|Publication status||Published - 26 Jan 2015|
Bibliographical note© 2015 Perez-Diaz and Mackenzie; This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
- molecular switch
FingerprintDive into the research topics of 'Linking Induction and Transrepression of PPARβ/δ with Cellular Function'. Together they form a unique fingerprint.
- School of Applied Sciences - Principal Lecturer
- Centre for Stress and Age-Related Disease